Effect of puerarin on vaginal connective tissue in patients with pelvic organ prolapse
نویسندگان
چکیده
Aims: The objective was to determine the impact of puerarin on the vaginal connective tissue of pelvic organ prolapse (POP) patients. Methods: We performed a prospective evaluation of patients who presented with POP between June 2010 and November 2012. Fifty-two women were enrolled and divided into a puerarin treatment group and control group. Patients in the puerarin group were treated with 0.429 mg/day puerarin for 30 days. The control group received placebo for 30 days. After treatment, all of patients accepted pelvic organ prolapse repair and biopsies of prolapsed tissue were obtained. Morphologic changes in the two groups were evaluated by light microscopy. The expression of elastin, collagen, neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP) and TGF-β was evaluated in all patients using immunohistochemistry. Result: Patients treated with puerarin had significantly less prolapse symptoms than control patients. Moreover, the expression of elastin, collagen, NPY, VIP and TGF-β was significantly increased in the puerarin group. Conclusion: Puerarin is a phytoestrogen that has therapeutic effects in patients with POP.
منابع مشابه
Histological Assessment of Vaginal Wall at Different Stages of Pelvic Organ Prolapse
Hypothesis / aims of study Collagen is ubiquitous in the human body and it is the main component of connective tissue. Several different types of collagen have been identified and is known that it is strongly represented in the vaginal wall and endopelvic fascia. Therefore collagen is the main component of the pelvic supporting structures and Pelvic Organ Prolapse (POP) is the clinical manifest...
متن کاملTransvaginal Sacrospinous Ligament Fixation for Pelvic Organ Prolapse Stage III and Stage IV Uterovaginal and Vault Prolapse
The result of transvaginal sacrospinous ligament fixation technique, as part of the vaginal repair procedure for massive uterovaginal (Pelvic Organ Prolapse stage III and stage IV and vault prolapse) is evaluated. A total of 32 women were included in the present case series. Marked uterovaginal prolapse was present in 28 women and four had vault prolapse following hysterectomy. Patients with va...
متن کاملبررسی فراوانی پرولاپس اعضای لگنی و ریسک فاکتورهای آن در زنان یائسه مراجعه کننده به بیمارستانهای دانشگاه علوم پزشکی ایران در سال1383
Background & Aim: Pelvic organ prolapse which is defined as displacement of bladder, uterus or rectum from their normal position downward is very common in elder women and causes significant morbidity. It is necessary to have a standard staging to investigate this problem, factors influencing it, and the effect of different therapeutic procedures on the course of disease. The aim of this st...
متن کاملThe Role of Altered Connective Tissue in the Causation of Pelvic Floor Symptoms
The pelvic floor consists of muscles and connective tissue. In the past, the components’ relative contribution to the structural support of the pelvic floor and its functions has been a subject of controversy (Corton 2009). With increasing age women can develop vaginal and pelvic organ prolapse as well as symptoms such as stress urinary incontinence, voiding dysfunction, urgency and frequency a...
متن کاملChanges in tissue composition of the vaginal wall of premenopausal women with prolapse.
OBJECTIVE The objective of this study was to compare histological and biochemical features of the (normal) precervical anterior vaginal wall and the prolapsed anterior vaginal wall of women with pelvic organ prolapse (POP). These data were compared to tissue of the precervical anterior vaginal wall of age-matched controls without POP to identify possible intrinsic and acquired effects. STUDY ...
متن کامل